There is no treatment that now allow to sustainably grow hair. Baldness, which affects about one in two men to 50 years in France, is an incurable disease. Only two molecules, minoxidil and finasteride, really slow hair loss (alopecia), sometimes inducing little regrowth. These treatments are still very heavy (application or taken daily for life), and far from being devoid of side effects - including libido.
A promising research laboratory hair culture, has made a big step thanks to a study published last year in the Proceedings of the American Academy of Sciences (PNAS) by a team led by the American Claire Higgins. Researchers from Columbia University (USA) and the University of Durham (UK) managed to recreate the hair follicles, hair factories, from dermal papilla, a set of cells located deep under the skin (the dermis). "The dermal papilla is like the conductor of the hair growth," says Bruno Bernard, head of laboratory research and L'Oreal hair Biology innovation. "This is what will cause intussusception scalp with a hair follicle, which will itself make the hair, guided by the papilla."
A hair reconstructed from a single root?
The papillae were taken at about 4 mm deep in the scalp of volunteers and then reimplanted in the skin of foreskin tissue naturally devoid of any hair that may disrupt the experience. This fabric is then grafted onto the back of a mouse, which serves as living carrier. Most have then induces the genesis of a follicle. American and English researchers are still gone further. "They have succeeded in cultivating these cells to multiply the dermal papillae virtually to infinity and reconstruct a three-dimensional structure by injecting 3,000 of these cells in a" hanging drop "," enthuses Bruno Bernard. "The cells, aggregating at the bottom of the drop, rebuilt spheroids." So far, human dermal papilla placed in 2D Culture losing their properties. What about these spheroids?
To find out, the researchers implanted them, as the taste buds in the skin of foreskin. And it worked. Between 15 to 60% of these structures induced the birth of a hair follicle. "This is a major advance," says Bruno Bernard. Hair transplant technique, or hair implants, is currently limited by the inability to multiply roots jacks on the back of the skull in the occipital area, to be brought back on the top of the skull. These new findings suggest that it may be possible in the near future to reconstruct an entire hair from a single root.
Growing hair in hand ...
"This is an important march crossed, but we're not yet at the top of the stairs," nevertheless tempers Bruno Bernard. If the follicles have been induced only two on the spheroids hundred grafted, did provide a skinny hair. "All genes inhibited by culturing has not been reactivated. It lacks such an expression of LEF-1, a key gene in hair growth, "says the French specialist of the follicle. We should also use tissue closest to the scalp as the foreskin. "Why not the tissue of the palm" to grow a coat in hand, provides the researcher with humor. A less innervated tissue but, in principle, equally hairless.
The price of hair transplantation in recent years HAS Evolved favorably. More people can now pay one and there are formulas Developed aussi That allow it to be paid in Installments.
A promising research laboratory hair culture, has made a big step thanks to a study published last year in the Proceedings of the American Academy of Sciences (PNAS) by a team led by the American Claire Higgins. Researchers from Columbia University (USA) and the University of Durham (UK) managed to recreate the hair follicles, hair factories, from dermal papilla, a set of cells located deep under the skin (the dermis). "The dermal papilla is like the conductor of the hair growth," says Bruno Bernard, head of laboratory research and L'Oreal hair Biology innovation. "This is what will cause intussusception scalp with a hair follicle, which will itself make the hair, guided by the papilla."
A hair reconstructed from a single root?
The papillae were taken at about 4 mm deep in the scalp of volunteers and then reimplanted in the skin of foreskin tissue naturally devoid of any hair that may disrupt the experience. This fabric is then grafted onto the back of a mouse, which serves as living carrier. Most have then induces the genesis of a follicle. American and English researchers are still gone further. "They have succeeded in cultivating these cells to multiply the dermal papillae virtually to infinity and reconstruct a three-dimensional structure by injecting 3,000 of these cells in a" hanging drop "," enthuses Bruno Bernard. "The cells, aggregating at the bottom of the drop, rebuilt spheroids." So far, human dermal papilla placed in 2D Culture losing their properties. What about these spheroids?
To find out, the researchers implanted them, as the taste buds in the skin of foreskin. And it worked. Between 15 to 60% of these structures induced the birth of a hair follicle. "This is a major advance," says Bruno Bernard. Hair transplant technique, or hair implants, is currently limited by the inability to multiply roots jacks on the back of the skull in the occipital area, to be brought back on the top of the skull. These new findings suggest that it may be possible in the near future to reconstruct an entire hair from a single root.
Growing hair in hand ...
"This is an important march crossed, but we're not yet at the top of the stairs," nevertheless tempers Bruno Bernard. If the follicles have been induced only two on the spheroids hundred grafted, did provide a skinny hair. "All genes inhibited by culturing has not been reactivated. It lacks such an expression of LEF-1, a key gene in hair growth, "says the French specialist of the follicle. We should also use tissue closest to the scalp as the foreskin. "Why not the tissue of the palm" to grow a coat in hand, provides the researcher with humor. A less innervated tissue but, in principle, equally hairless.
The price of hair transplantation in recent years HAS Evolved favorably. More people can now pay one and there are formulas Developed aussi That allow it to be paid in Installments.
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